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TSET-funded Grant Represented at the Society of Research on Nicotine and Tobacco Annual Meeting

Representatives from the Oklahoma Tobacco Research Center at the Stephenson Cancer Center presented at the Society of Research on Nicotine and Tobacco (SRNT) Annual Meeting in Baltimore in March. In total, 23 posters were presented at the national conference that disseminates new research on nicotine.

Researchers participated in a pre-conference workshop on smartphone-based assessments and interventions for smoking cessation, delivered three oral presentations, and presented 22 posters. Three researchers were also awarded scholarships to attend and present on health disparities related research.

Topics of the presentations ranged from the court-ordered corrective statements to tobacco regulatory science to tobacco cessation interventions in vulnerable and underserved populations. Three researchers were also awarded scholarships to attend and present their research at the Society of Research on Nicotine and Tobacco.

SRNT Presentations and Posters

Preconference Workshop

Businelle, M. S. Developing and Testing Smartphone Based Assessments and Interventions for Smokers. (February 2018). Part of the SRNT Treatment Network’s Preconference Workshop on Innovations in Tobacco Treatment Research: New Treatments and Methodologies. Baltimore, MD.

Dr. Businelle discussed his work using Ecological Momentary Assessment (EMA) data to estimate imminent risk of smoking lapse and intervene in real time with Just-in-Time Adaptive Interventions (JITAI). He also provided an overview of the versatile Insight mHealth Platform which facilitates the development of advanced mobile apps that aim to prevent cancer and other chronic diseases (i.e., mental, physical), supplement treatments, and improve quality of life.

Oral Presentations

  1. Court-Ordered Corrections of Tobacco Company Racketeering: Awareness, Attitudes, and Implications for Tobacco Control Policy. Doug Matheny, Elise Stevens & Xixia Chen. Oral presentation at the Society for Research on Nicotine and Tobacco 24th Annual Meeting, February 21-24, 2018, Baltimore, MD.

Highlighted results from a recent national poll suggesting that awareness of the corrective statements and related court findings increases public support for tobacco control policies and for rejecting tobacco company influences in policymaking.

  1. Children’s uptake of tobacco-related toxicants while living in vaping, smoking and non-tobacco using homes. Theodore Wagener*, David Fedele, Elise Turner, Irina Stephanov, Alexis Moisiuc, Jessica Son, Neil Molina, Eleanor Leavens, Raees Shaikh.

The present study examined the level of cotinine (nicotine biomarker) and NNAL (potent lung carcinogen) among children living with a parent(s) who neither vaped nor smoked (non-user), only vaped, or only smoked, and assessed parental smoking/vaping behavior, and rules about smoking/vaping in the home.

  1. Electronic Cigarette aerosols induce DNA damage and decrease repair. Queimado L, Manyanga J, Brame L, McGuire D, Sadhasivam B, Floyd E, Brobst D, Zhao D, Rubenstein D,  Wagener T, Ramachandran I, and V Ganapathy. Oral presentation at the Society for Research on Nicotine and Tobacco 24th Annual Meeting, February 21-24, 2018, Baltimore, MD.

EC are promoted as a safer alternative to tobacco cigarettes and a promising smoking cessation aid. Nonetheless, EC aerosols contain unique toxicants, as well as carcinogens and reactive oxygen species (ROS) that are also present in tobacco smoke. We have previously reported that EC aerosols can cause DNA damage. Here we determined the sensitivity of diverse methods to detect DNA damage induced by EC aerosols and to investigate the mechanisms by which EC use can contribute to DNA damage. We showed that EC aerosols cause less damage than tobacco smoke. Nonetheless, ECs cause significant DNA damage detectable by several assays, including lesions that are highly mutagenic and can lead to cancer. Moreover, exposure to EC aerosol also decreased the cellular antioxidant and DNA damage repair capability, potentially increasing cancer risk associated with exposure to other genotoxics. Our data emphasize the urgent need to further evaluate EC safety to ensure evidence-based public health policies and regulations.

Poster Presentations

  1. Geller, D., Hébert, E.T., Kendzor, D.E., & Businelle, M.S. (2018, February). Predicting Risk of Imminent Smoking Lapse in Real Time Using Machine Learning. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

Presented a machine learning analysis of the Prevail 2 dataset to identify predictors of smoking relapse.  Duration since last smoke was an important variable, as well as several measures of self-efficacy.  An 80% AUC for predicting relapse was achieved using these variables.

  1. Hébert, E.T., Stevens, E.M., Frank, S.G., Kendzor, D.E., & Businelle, M.S. (2018, February). An Ecological Momentary Intervention for Smoking Cessation: The Associations of Just-in-Time, Tailored Messages with Lapse Risk Factors. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

 

  1. Helt, A., Hébert, E. T., Moisiuc, R., Kendzor, D. E., Vidrine, D. J., & Businelle, M. S. (2018, February). A Qualitative Look at Participant Reactions to a Smartphone-Based Smoking Cessation Treatment. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

Thematic analysis of qualitative interviews in this pilot study was conducted to assess participant feedback on smartphone based ecological momentary assessments (EMA). Findings showed participants preferred tailored messages over consistent and repetitive EMAs. Triangulation of qualitative data with quantitative surveys could help inform design in future smartphone research.

  1. Hollins, P., Hébert, E. T., Businelle, M. S., & Kendzor, D. E. (2018, February). The Influence of Mental Health on Smoking Cessation among Socioeconomically Disadvantaged Safety Net Hospital Patients. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

The purpose this study was to describe the mental health of adults seeking treatment at a safety net hospital smoking cessation clinic, and to characterize the influence of mental health on smoking cessation. Findings indicated that participants with probable major depressive disorder and other indicators of distress were significantly more likely to be non-abstinent 4 weeks after a quit attempt.

  1. Moisiuc, R., Hébert, E. T., Vidrine, J. I., Vidrine, D. J., Businelle, M. S., & Kendzor, D. E. (2018, February). The Tobacco Treatment Research Program: Integrating Research and Practice. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

We examined participant demographics and quit rates from the Tobacco Treatment Research Program at the OTRC. The majority of participants were female, white, and about half reported a family income less than $20,000. At the 6-month follow-up, 13.5% of participants were biochemically verified abstinent and an additional 3.5% self-reported abstinence.

  1. Roys, M., R., Waters, A. F., Stewart, S. A., Copeland, A. L., Businelle, M. S., & Kendzor, D. E. (2018, February). Depression Mediates the Relationship between Subjective Social Status and Smoking Status in a Community Sample of Adults. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

Mediation analyses were conducted to evaluate the indirect effects of Subjective Social Status on smoking status through depression symptoms. Findings suggested that depression could be an underlying mechanism through which SSS influences smoking.

  1. Waring, J. J. C., Hébert, E. T., Businelle, M. S., & Kendzor, D. E. (2018, February). Evaluating the Influences of Social Pressure and Support on Daily Smoking Abstinence.  Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

This study used post-quit Ecological Momentary Assessment (EMA) data to examine the relationship between social influences and daily smoking abstinence. We found that the odds of lapse were higher on days when participants were offered a cigarette by others compared to days when no such event occurred.

  1. Waters, A. F., Kendzor, D. E., Roys, M. E., Stewart, S. A., & Copeland, A. L. Identifying Stress-Related Variables Linking Socioeconomic Status and Smoking Status. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

Stress variables were examined as potential mediators between socioeconomic status (education) and smoking status (smoker vs. non-smoker). Findings indicated that lower socioeconomic status predicted greater financial strain, which in turn predicted a greater probability of being a smoker.

  1. Shore, M. Vidrine, J. I., Hébert, E., Frank, S., Amil, M., Businelle, M. S., Vidrine, D. J. (2018, February). Feasibility and preliminary efficacy of smartphone-delivered automated video-assisted smoking cessation treatment. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

 

  1. Neisler, J, Reitzel, L. R., Kendzor, D. E., Hébert, E. T., Vijayaraghavan, M., & Businelle, M. S. (2018, February). Examining the Moderating Effect of Perceived Social Support on Heaviness of Smoking and Quit Attempts Among Adult Homeless Smokers. Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore MD.

Data from 6 homeless-serving shelters in Oklahoma where increased cigarette dependence was found to negatively related to successful 24-hour quit attempts. Results of a moderation analysis showed that the perceived social support, ex. the availability of someone to talk to about one's problems, appeared to attenuate the strength of the inverse relationship between cigarette dependence and successful 24-hour quit attempts. This suggests that fostering social support among homeless smokers may reduce the impact that cigarette dependence has on making quit attempts.

  1. Hébert, E.T., Businelle, M. S., Kendzor, D. E., Helt, A., Moisiuc, R., & Vidrine, D. J. (2018, February). Pilot Randomized Clinical Trial of an Automated Smartphone-Based Smoking Cessation Treatment (part of Mobile Health Approaches for Reducing Smoking-Related Health Disparities). Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco, Baltimore, MD.

 

  1. Kendzor, D. E., Businelle, M. S., Vidrine, D. J., Casiano, N., Mathews, A. J., Geller, D., & Aguirre, M. M. (2018, February). Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults (part of Mobile Health Approaches for Reducing Smoking-Related Health Disparities). Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco. Baltimore, MD.

Presented the “PrevailGO” smartphone app that will remotely verify smoking abstinence, confirm participant identity, and automatically deliver financial incentives when self-reported abstinence is biochemically confirmed.

  1. Ask-Advise-Connect: Counseling treatment adherence influences Quitline treatment outcomes among safety net healthcare system patients. Bárbara Piñeiro, Diana S. Hoover, Damon J. Vidrine, David W. Wetter, Summer G. Frank, Nga Nguyen, Jennifer I. Vidrine. ). Poster presented at the annual meeting of the Society for Research on Nicotine and Tobacco. Baltimore, MD.

The current study presents data emanating from a 34-month implementation study evaluating Ask-Advise-Connect (an Electronic Health Record) in 13 community health clinics. We examined associations between quitline counseling treatment dose and cessation outcomes 6 months following treatment enrollment. We found that counseling dose received was positively associated with smoking abstinence; specifically receipt of 2 counseling calls doubled the odds of achieving abstinence, and receipt of ≥ three (vs. no) calls nearly quadrupled abstinence rates.  Therefore, improving quitline treatment engagement and adherence is a critically important research priority.

  1. THE EFFECT OF A UNIVERSITY-WIDE BAN OF ELECTRONIC CIGARETTES ON TOBACCO USE PATTERNS. Alexis Moisiuc*, Eleanor Leavens, Elise Stevens, Emma Brett, Theodore Wagener.

While the e-cigarette (EC) ban did not directly prevent experimentation with ECs, it may have kept regular use at bay during a time in which EC use was proliferating nationally. The tobacco landscape is changing rapidly and the current study has implications for public health and future policies related to emerging products.

  1. IT’S A TRAP! AN EXAMINATION OF WATERPIPE SMOKERS AND NON-SMOKERS’ REACTIONS TO ANTI-WATERPIPE PSAS. Elise Stevens*, Seunghyun Seunghyun, Glenn Leshner, Eleanor Leavens, Jennifer Vidrine, Summer Frank, Theodore Wagener.

In order to communicate the risks of WP smoking, public service announcements (PSAs) have been employed. Research has examined the effects of anti-cigarette PSAs, but no research has examined the effects of anti-WP PSAs on WP smokers and WP non-smokers.

  1. UNDERSTANDING THE ROLE OF ALCOHOL CONSUMPTION IN WATERPIPE TOBACCO SMOKING TOPOGRAPHY, TOXICANT EXPOSURE, AND SMOKING EXPERIENCE. Eleanor Leavens*, Taylor Morgan, Kelsey Lee, Jessica Son, Emma Brett, Thomas Eissenberg, Alan Shihadeh, Theodore Wagener.

Concurrent alcohol consumption and waterpipe (WP) tobacco smoking is common and may be associated with increased toxicant exposure compared to WP smoking alone. In this controlled, randomized crossover trial, alcohol consumption was consistently associated with an enhanced and longer smoking experience, indicating a potential need for regulations of alcohol sales in WP lounges.

  1. DESCRIPTIVE AND INJUNCTIVE NORMS OF WATERPIPE TOBACCO SMOKING AMONG COLLEGE STUDENTS. Eleanor Leavens*, Emma Brett, Taylor Morgan, Susanna Lopez, Raees Shaikh, Thad Leffingwell, Theodore Wagener.

The current study examined the perceived and actual descriptive and injunctive norms of WP tobacco smoking among a college student sample.

  1. AN ANALYSIS OF JUUL DISCUSSIONS ON SOCIAL MEDIA: USING REDDIT TO UNDERSTAND PATTERNS OF USE AND PERCEPTIONS OF JUUL. Emma Brett*, Emily Hébert, Elise Stevens, Eleanor Leavens, Taylor Morgan, Theodore Wagener.

The current study examined patterns of use and perceptions of JUUL using publicly available data from Reddit.com, which remains one of the most popular websites worldwide and contains numerous forums dedicated to noncombustible tobacco products.

  1. ARE THERE DIFFERENCES IN VAPE SHOP POINT-OF-SALE MARKETINGAS A FUNCTION OF PROXIMITY TO SCHOOLS? Raees Shaikh, Dana Carroll, Eleanor L. Leavens, Amelia Wedel, Neil Molina, Laura Beebe, Theodore L. Wagener.

This poster presented research examining whether the point-of-sale (POS) marketing practices and neighborhood socio-demographic characteristics of vape shops differ according to their proximity to schools.

  1. IMPACT OF FLAVORS AND SWEETENERS ON WATERPIPE TOBACCO SMOKING. Theodore Wagener*, Eleanor Leavens, Jessica Son, Taylor Morgan, Thomas Eissenberg, Alan Shihadeh, Summer Frank.

The current study suggests that flavors and sweeteners from waterpipe tobacco significantly influence the product’s abuse liability and users’ reported willingness and interest for continued use.